4-Hydroxynonenal contributes to NGF withdrawal-induced neuronal apoptosis
نویسندگان
چکیده
منابع مشابه
Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.
Oxidative stress is believed to play important roles in neuronal cell death associated with many different neurodegenerative conditions (e.g., Alzheimer's disease, Parkinson's disease, and cerebral ischemia), and it is believed also that apoptosis is an important mode of cell death in these disorders. Membrane lipid peroxidation has been documented in the brain regions affected in these disorde...
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We have previously demonstrated that neuronal microtubules are exquisitely sensitive to the lipid peroxidation product 4-hydroxynonenal (HNE). The mechanism, however, by which HNE disrupts the microtubules, is not known. Sulfhydryl groups of protein-cysteines constitute main targets of HNE. Indeed, HNE is mainly detoxified by conjugation to glutathione (GSH), a reaction that leads to depletion ...
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The aim of this study was to investigate whether apoptosis contributes to nephrotoxicity caused by amphotericin B (AmB). By detecting apoptosis-specific DNA fragmentation, it is demonstrated that proximal tubular cells (LLC-PK(1)) and medullary interstitial cells (RMIC) respond with programmed cell death when treated with therapeutic doses of AmB. Concomitant application of AmB and recombinant ...
متن کامل4-Hydroxynonenal Induces Endothelial Apoptosis through Mitochondrial Depolarization
Young Mi Kwon, Jaewon Lee, Hyung Suk Baik, Byung Pal Yu and Hae Young Chung* College of Pharmacy, Pusan National University, Busan 609-735, Korea MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Busan 602-739, Korea 3 Genetic Engineering Research Institute, Pusan National University, Busan, 609-735, Korea Department of Physiology, The University of Texas Hea...
متن کاملKaempferol attenuates 4-hydroxynonenal-induced apoptosis in PC12 cells by directly inhibiting NADPH oxidase.
Kaempferol, a natural flavonoid isolated from various plant sources, has been identified as a potential neuroprotectant. In this study, we investigated the protective effect of kaempferol against 4-hydroxynonenal (HNE)-induced apoptosis in PC12 rat pheochromocytoma cells. Kaempferol inhibited 4-HNE-mediated apoptosis, characterized by nuclear condensation, down-regulation of antiapoptotic prote...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2003
ISSN: 0022-3042,1471-4159
DOI: 10.1046/j.1471-4159.2003.01749.x